MuSiC (Mutational Significance in Cancer) 0.3 is now available for download featuring numerous fixes and several new features. MuSiC performs a variety of statistical analyses on the somatic (and germline) alterations discovered in any cancer cohort. Improvements in this version include an enhanced significantly mutated gene test which introduces the ability to 1) take into account sample-specific mutation rates and 2) identify significantly mutated non-genic regions of the genome. The clinical correlation module now features a generalized linear model option allowing for the elimination of covariate influences on mutation-phenotype relationships. Support for MAF 2.2 and for Pfam annotation of GRCh37 (hg19) are now standard. Additionally, several MuSiC components have been optimized and parallelized for faster execution.
April 27, 2012